Zia Khan and colleagues publish Science paper on the evolution of protein expression

CBCB faculty Zia Khan is the first author on a new study appearing in the journal Science. Prof. Khan's work, performed in his prior position at the University of Chicago, demonstrates that protein levels are more strongly conserved during evolution than the levels of the transcripts from which these proteins are translated. While this observation makes sense - proteins are the workhorse in cells and their levels must be tightly controlled - Prof. Khan's work is the first to disentangle the experimental noise from biological signal, thereby conclusively demonstrating this effect. A more detailed perspective on this study, written by Christine Vogel appeared in the same Science issue under the title Protein Expression Under Pressure .