Recurring genomic breaks in independent lineages support genomic fragility

TitleRecurring genomic breaks in independent lineages support genomic fragility
Publication TypeJournal Articles
Year of Publication2006
AuthorsHinsch H, Hannenhalli S
JournalBMC Evolutionary BiologyBMC Evolutionary Biology
Volume6
Type of Article10.1186/1471-2148-6-90
ISBN Number1471-2148
Abstract

Recent findings indicate that evolutionary breaks in the genome are not randomly distributed, and that certain regions, so-called fragile regions, are predisposed to breakages. Previous approaches to the study of genomic fragility have examined the distribution of breaks, as well as the coincidence of breaks with segmental duplications and repeats, within a single species. In contrast, we investigate whether this regional fragility is an inherent genomic characteristic and is thus conserved over multiple independent lineages.