@article {38203,
	title = {Differential abundance analysis for microbial marker-gene surveys},
	journal = {Nature methods},
	volume = {10},
	year = {2013},
	publisher = {Nature Publishing Group},
	chapter = {1200},
	abstract = {We introduce a methodology to assess differential abundance in sparse high-throughput microbial marker-gene survey data. Our approach, implemented in the metagenomeSeq Bioconductor package, relies on a novel normalization technique and a statistical model that accounts for undersampling{\textemdash}a common feature of large-scale marker-gene studies. Using simulated data and several published microbiota data sets, we show that metagenomeSeq outperforms the tools currently used in this field.},
	isbn = {1548-7091},
	doi = {10.1038/nmeth.2658},
	url = {http://www.nature.com/nmeth/journal/v10/n12/full/nmeth.2658.html},
	author = {Joseph N. Paulson and Stine, O. Colin and H{\'e}ctor Corrada Bravo and M. Pop}
}
