TY - JOUR T1 - Genome assembly forensics: finding the elusive mis-assembly JF - Genome BiologyGenome Biology Y1 - 2008 A1 - Phillippy, Adam M. A1 - Schatz, Michael C. A1 - M. Pop AB - We present the first collection of tools aimed at automated genome assembly validation. This work formalizes several mechanisms for detecting mis-assemblies, and describes their implementation in our automated validation pipeline, called amosvalidate. We demonstrate the application of our pipeline in both bacterial and eukaryotic genome assemblies, and highlight several assembly errors in both draft and finished genomes. The software described is compatible with common assembly formats and is released, open-source, at http://amos.sourceforge.net. VL - 9 SN - 1465-6906 ER -