TY - JOUR T1 - InterPro: the integrative protein signature database JF - Nucleic acids researchNucleic Acids Research Y1 - 2009 A1 - Hunter, Sarah A1 - Apweiler, Rolf A1 - Attwood, Teresa K. A1 - Bairoch, Amos A1 - Bateman, Alex A1 - Binns, David A1 - Bork, Peer A1 - Das, Ujjwal A1 - Daugherty, Louise A1 - Duquenne, Lauranne A1 - Finn, Robert D. A1 - Gough, Julian A1 - Haft, Daniel A1 - Hulo, Nicolas A1 - Kahn, Daniel A1 - Kelly, Elizabeth A1 - Laugraud, Aurélie A1 - Letunic, Ivica A1 - Lonsdale, David A1 - Lopez, Rodrigo A1 - Madera, Martin A1 - Maslen, John A1 - McAnulla, Craig A1 - McDowall, Jennifer A1 - Mistry, Jaina A1 - Mitchell, Alex A1 - Mulder, Nicola A1 - Natale, Darren A1 - Orengo, Christine A1 - Quinn, Antony F. A1 - J. Selengut A1 - Sigrist, Christian J. A. A1 - Thimma, Manjula A1 - Thomas, Paul D. A1 - Valentin, Franck A1 - Wilson, Derek A1 - Wu, Cathy H. A1 - Yeats, Corin KW - Databases, Protein KW - Proteins KW - Sequence Analysis, Protein KW - Systems Integration AB - The InterPro database (http://www.ebi.ac.uk/interpro/) integrates together predictive models or 'signatures' representing protein domains, families and functional sites from multiple, diverse source databases: Gene3D, PANTHER, Pfam, PIRSF, PRINTS, ProDom, PROSITE, SMART, SUPERFAMILY and TIGRFAMs. Integration is performed manually and approximately half of the total approximately 58,000 signatures available in the source databases belong to an InterPro entry. Recently, we have started to also display the remaining un-integrated signatures via our web interface. Other developments include the provision of non-signature data, such as structural data, in new XML files on our FTP site, as well as the inclusion of matchless UniProtKB proteins in the existing match XML files. The web interface has been extended and now links out to the ADAN predicted protein-protein interaction database and the SPICE and Dasty viewers. The latest public release (v18.0) covers 79.8% of UniProtKB (v14.1) and consists of 16 549 entries. InterPro data may be accessed either via the web address above, via web services, by downloading files by anonymous FTP or by using the InterProScan search software (http://www.ebi.ac.uk/Tools/InterProScan/). VL - 37 N1 - http://www.ncbi.nlm.nih.gov/pubmed/18940856?dopt=Abstract ER -