TY - JOUR
T1 - The genome sequence of Drosophila melanogaster.
JF - Science
Y1 - 2000
A1 - Adams, M D
A1 - Celniker, S E
A1 - Holt, R A
A1 - Evans, C A
A1 - Gocayne, J D
A1 - Amanatides, P G
A1 - Scherer, S E
A1 - Li, P W
A1 - Hoskins, R A
A1 - Galle, R F
A1 - George, R A
A1 - Lewis, S E
A1 - Richards, S
A1 - Ashburner, M
A1 - Henderson, S N
A1 - Sutton, G G
A1 - Wortman, J R
A1 - Yandell, M D
A1 - Zhang, Q
A1 - Chen, L X
A1 - Brandon, R C
A1 - Rogers, Y H
A1 - Blazej, R G
A1 - Champe, M
A1 - Pfeiffer, B D
A1 - Wan, K H
A1 - Doyle, C
A1 - Baxter, E G
A1 - Helt, G
A1 - Nelson, C R
A1 - Gabor, G L
A1 - Abril, J F
A1 - Agbayani, A
A1 - An, H J
A1 - Andrews-Pfannkoch, C
A1 - Baldwin, D
A1 - Ballew, R M
A1 - Basu, A
A1 - Baxendale, J
A1 - Bayraktaroglu, L
A1 - Beasley, E M
A1 - Beeson, K Y
A1 - Benos, P V
A1 - Berman, B P
A1 - Bhandari, D
A1 - Bolshakov, S
A1 - Borkova, D
A1 - Botchan, M R
A1 - Bouck, J
A1 - Brokstein, P
A1 - Brottier, P
A1 - Burtis, K C
A1 - Busam, D A
A1 - Butler, H
A1 - Cadieu, E
A1 - Center, A
A1 - Chandra, I
A1 - Cherry, J M
A1 - Cawley, S
A1 - Dahlke, C
A1 - Davenport, L B
A1 - Davies, P
A1 - de Pablos, B
A1 - Delcher, A
A1 - Deng, Z
A1 - Mays, A D
A1 - Dew, I
A1 - Dietz, S M
A1 - Dodson, K
A1 - Doup, L E
A1 - Downes, M
A1 - Dugan-Rocha, S
A1 - Dunkov, B C
A1 - Dunn, P
A1 - Durbin, K J
A1 - Evangelista, C C
A1 - Ferraz, C
A1 - Ferriera, S
A1 - Fleischmann, W
A1 - Fosler, C
A1 - Gabrielian, A E
A1 - Garg, N S
A1 - Gelbart, W M
A1 - Glasser, K
A1 - Glodek, A
A1 - Gong, F
A1 - Gorrell, J H
A1 - Gu, Z
A1 - Guan, P
A1 - Harris, M
A1 - Harris, N L
A1 - Harvey, D
A1 - Heiman, T J
A1 - Hernandez, J R
A1 - Houck, J
A1 - Hostin, D
A1 - Houston, K A
A1 - Howland, T J
A1 - Wei, M H
A1 - Ibegwam, C
A1 - Jalali, M
A1 - Kalush, F
A1 - Karpen, G H
A1 - Ke, Z
A1 - Kennison, J A
A1 - Ketchum, K A
A1 - Kimmel, B E
A1 - Kodira, C D
A1 - Kraft, C
A1 - Kravitz, S
A1 - Kulp, D
A1 - Lai, Z
A1 - Lasko, P
A1 - Lei, Y
A1 - Levitsky, A A
A1 - Li, J
A1 - Li, Z
A1 - Liang, Y
A1 - Lin, X
A1 - Liu, X
A1 - Mattei, B
A1 - McIntosh, T C
A1 - McLeod, M P
A1 - McPherson, D
A1 - Merkulov, G
A1 - Milshina, N V
A1 - Mobarry, C
A1 - Morris, J
A1 - Moshrefi, A
A1 - Mount, S M
A1 - Moy, M
A1 - Murphy, B
A1 - Murphy, L
A1 - Muzny, D M
A1 - Nelson, D L
A1 - Nelson, D R
A1 - Nelson, K A
A1 - Nixon, K
A1 - Nusskern, D R
A1 - Pacleb, J M
A1 - Palazzolo, M
A1 - Pittman, G S
A1 - Pan, S
A1 - Pollard, J
A1 - Puri, V
A1 - Reese, M G
A1 - Reinert, K
A1 - Remington, K
A1 - Saunders, R D
A1 - Scheeler, F
A1 - Shen, H
A1 - Shue, B C
A1 - SidÃ©n-Kiamos, I
A1 - Simpson, M
A1 - Skupski, M P
A1 - Smith, T
A1 - Spier, E
A1 - Spradling, A C
A1 - Stapleton, M
A1 - Strong, R
A1 - Sun, E
A1 - Svirskas, R
A1 - Tector, C
A1 - Turner, R
A1 - Venter, E
A1 - Wang, A H
A1 - Wang, X
A1 - Wang, Z Y
A1 - Wassarman, D A
A1 - Weinstock, G M
A1 - Weissenbach, J
A1 - Williams, S M
A1 - Worley, K C
A1 - Wu, D
A1 - Yang, S
A1 - Yao, Q A
A1 - Ye, J
A1 - Yeh, R F
A1 - Zaveri, J S
A1 - Zhan, M
A1 - Zhang, G
A1 - Zhao, Q
A1 - Zheng, L
A1 - Zheng, X H
A1 - Zhong, F N
A1 - Zhong, W
A1 - Zhou, X
A1 - Zhu, S
A1 - Zhu, X
A1 - Smith, H O
A1 - Gibbs, R A
A1 - Myers, E W
A1 - Rubin, G M
A1 - Venter, J C
KW - Animals
KW - Biological Transport
KW - Chromatin
KW - Cloning, Molecular
KW - Computational Biology
KW - Contig Mapping
KW - Cytochrome P-450 Enzyme System
KW - DNA Repair
KW - DNA Replication
KW - Drosophila melanogaster
KW - Euchromatin
KW - Gene Library
KW - Genes, Insect
KW - Genome
KW - Heterochromatin
KW - Insect Proteins
KW - Nuclear Proteins
KW - Protein Biosynthesis
KW - Sequence Analysis, DNA
KW - Transcription, Genetic
AB - The fly Drosophila melanogaster is one of the most intensively studied organisms in biology and serves as a model system for the investigation of many developmental and cellular processes common to higher eukaryotes, including humans. We have determined the nucleotide sequence of nearly all of the approximately 120-megabase euchromatic portion of the Drosophila genome using a whole-genome shotgun sequencing strategy supported by extensive clone-based sequence and a high-quality bacterial artificial chromosome physical map. Efforts are under way to close the remaining gaps; however, the sequence is of sufficient accuracy and contiguity to be declared substantially complete and to support an initial analysis of genome structure and preliminary gene annotation and interpretation. The genome encodes approximately 13,600 genes, somewhat fewer than the smaller Caenorhabditis elegans genome, but with comparable functional diversity.

VL - 287
CP - 5461
ER -