TY - JOUR T1 - Three independent determinants of protein evolutionary rate JF - J Mol EvolJ Mol EvolJ Mol Evol Y1 - 2013 A1 - Choi, S. S. A1 - Sridhar Hannenhalli KW - *Evolution, Molecular KW - *Mutation Rate KW - Animals KW - Genes/physiology KW - Genetic Fitness KW - HUMANS KW - Models, Genetic KW - Protein Biosynthesis/genetics KW - Protein Folding KW - Protein Interaction Domains and Motifs/genetics KW - Proteins/chemistry/*genetics/metabolism AB - One of the most widely accepted ideas related to the evolutionary rates of proteins is that functionally important residues or regions evolve slower than other regions, a reasonable outcome of which should be a slower evolutionary rate of the proteins with a higher density of functionally important sites. Oddly, the role of functional importance, mainly measured by essentiality, in determining evolutionary rate has been challenged in recent studies. Several variables other than protein essentiality, such as expression level, gene compactness, protein-protein interactions, etc., have been suggested to affect protein evolutionary rate. In the present review, we try to refine the concept of functional importance of a gene, and consider three factors-functional importance, expression level, and gene compactness, as independent determinants of evolutionary rate of a protein, based not only on their known correlation with evolutionary rate but also on a reasonable mechanistic model. We suggest a framework based on these mechanistic models to correctly interpret the correlations between evolutionary rates and the various variables as well as the interrelationships among the variables. VL - 76 SN - 1432-1432 (Electronic)
0022-2844 (Linking) N1 - Choi, Sun Shim
Hannenhalli, Sridhar
eng
R01GM085226/GM/NIGMS NIH HHS/
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Germany
2013/02/13 06:00
J Mol Evol. 2013 Mar;76(3):98-111. doi: 10.1007/s00239-013-9543-6. Epub 2013 Feb 12. J1 - Journal of molecular evolutionJournal of molecular evolution ER -