Genome Sequence of Hybrid Vibrio Cholerae O1 MJ-1236, B-33, and CIRS101 and Comparative Genomics with V. Cholerae
| Title | Genome Sequence of Hybrid Vibrio Cholerae O1 MJ-1236, B-33, and CIRS101 and Comparative Genomics with V. Cholerae |
| Publication Type | Journal Articles |
| Year of Publication | 2010 |
| Authors | Grim CJ, Hasan NA, Taviani E, Haley B, Jongsik C, Brettin TS, Bruce DC, J. Detter C, Han CS, Chertkov O, Challacombe J, Huq A, G. Nair B, Colwell RR |
| Journal | Journal of BacteriologyJ. Bacteriol.Journal of BacteriologyJ. Bacteriol. |
| Volume | 192 |
| Type of Article | 10.1128/JB.00040-10 |
| ISBN Number | 0021-9193, 1098-5530 |
| Abstract | The genomes of Vibrio cholerae O1 Matlab variant MJ-1236, Mozambique O1 El Tor variant B33, and altered O1 El Tor CIRS101 were sequenced. All three strains were found to belong to the phylocore group 1 clade of V. cholerae, which includes the 7th-pandemic O1 El Tor and serogroup O139 isolates, despite displaying certain characteristics of the classical biotype. All three strains were found to harbor a hybrid variant of CTXΦ and an integrative conjugative element (ICE), leading to their establishment as successful clinical clones and the displacement of prototypical O1 El Tor. The absence of strain- and group-specific genomic islands, some of which appear to be prophages and phage-like elements, seems to be the most likely factor in the recent establishment of dominance of V. cholerae CIRS101 over the other two hybrid strains. |