InterPro: the integrative protein signature database.

TitleInterPro: the integrative protein signature database.
Publication TypeJournal Articles
Year of Publication2009
AuthorsHunter S, Apweiler R, Attwood TK, Bairoch A, Bateman A, Binns D, Bork P, Das U, Daugherty L, Duquenne L, Finn RD, Gough J, Haft D, Hulo N, Kahn D, Kelly E, Laugraud A, Letunic I, Lonsdale D, Lopez R, Madera M, Maslen J, McAnulla C, McDowall J, Mistry J, Mitchell A, Mulder N, Natale D, Orengo C, Quinn AF, Selengut JD, Sigrist CJA, Thimma M, Thomas PD, Valentin F, Wilson D, Wu CH, Yeats C
JournalNucleic Acids Res
IssueDatabase issue
Date Published2009 Jan
KeywordsDatabases, Protein, Proteins, Sequence Analysis, Protein, Systems Integration

The InterPro database ( integrates together predictive models or 'signatures' representing protein domains, families and functional sites from multiple, diverse source databases: Gene3D, PANTHER, Pfam, PIRSF, PRINTS, ProDom, PROSITE, SMART, SUPERFAMILY and TIGRFAMs. Integration is performed manually and approximately half of the total approximately 58,000 signatures available in the source databases belong to an InterPro entry. Recently, we have started to also display the remaining un-integrated signatures via our web interface. Other developments include the provision of non-signature data, such as structural data, in new XML files on our FTP site, as well as the inclusion of matchless UniProtKB proteins in the existing match XML files. The web interface has been extended and now links out to the ADAN predicted protein-protein interaction database and the SPICE and Dasty viewers. The latest public release (v18.0) covers 79.8% of UniProtKB (v14.1) and consists of 16 549 entries. InterPro data may be accessed either via the web address above, via web services, by downloading files by anonymous FTP or by using the InterProScan search software (

Alternate JournalNucleic Acids Res.
PubMed ID18940856
PubMed Central IDPMC2686546
Grant List087656 / / Wellcome Trust / United Kingdom
BB/F010435/1 / / Biotechnology and Biological Sciences Research Council / United Kingdom
BB/F010508/1 / / Biotechnology and Biological Sciences Research Council / United Kingdom
GM081084 / GM / NIGMS NIH HHS / United States
/ / Wellcome Trust / United Kingdom