Reduction of Cholera in Bangladeshi Villages by Simple Filtration

TitleReduction of Cholera in Bangladeshi Villages by Simple Filtration
Publication TypeJournal Articles
Year of Publication2003
AuthorsColwell RR, Huq A, M. Islam S, Aziz K.MA, Yunus M., N. Khan H, Mahmud A., R. Sack B, Nair G.B, Chakraborty J., Sack DA, Russek-Cohen E.
JournalProceedings of the National Academy of SciencesPNASProceedings of the National Academy of SciencesPNAS
Type of Article10.1073/pnas.0237386100
ISBN Number0027-8424, 1091-6490

Based on results of ecological studies demonstrating that Vibrio cholerae, the etiological agent of epidemic cholera, is commensal to zooplankton, notably copepods, a simple filtration procedure was developed whereby zooplankton, most phytoplankton, and particulates >20 μm were removed from water before use. Effective deployment of this filtration procedure, from September 1999 through July 2002 in 65 villages of rural Bangladesh, of which the total population for the entire study comprised ≈133,000 individuals, yielded a 48% reduction in cholera (P < 0.005) compared with the control.