Searching for SNPs with cloud computing

TitleSearching for SNPs with cloud computing
Publication TypeJournal Articles
Year of Publication2009
AuthorsLangmead B, Schatz MC, Jimmy L, Pop M., Salzberg SL
JournalGenome BiologyGenome Biology
Type of Article10.1186/gb-2009-10-11-r134
ISBN Number1465-6906

As DNA sequencing outpaces improvements in computer speed, there is a critical need to accelerate tasks like alignment and SNP calling. Crossbow is a cloud-computing software tool that combines the aligner Bowtie and the SNP caller SOAPsnp. Executing in parallel using Hadoop, Crossbow analyzes data comprising 38-fold coverage of the human genome in three hours using a 320-CPU cluster rented from a cloud computing service for about $85. Crossbow is available from