The Theory and Practice of Genome Sequence Assembly

TitleThe Theory and Practice of Genome Sequence Assembly
Publication TypeJournal Articles
Year of Publication2015
AuthorsSimpson J.T, Pop M.
JournalAnnu Rev Genomics Hum GenetAnnu Rev Genomics Hum Genet
Date PublishedAug 24
ISBN Number1545-293X (Electronic)<br/>1527-8204 (Linking)
Accession Number25939056
Keywordsalgorithm, Bioinformatics, genome sequencing, sequence assembly, shotgun sequencing
AbstractThe current genomic revolution was made possible by joint advances in genome sequencing technologies and computational approaches for analyzing sequence data. The close interaction between biologists and computational scientists is perhaps most apparent in the development of approaches for sequencing entire genomes, a feat that would not be possible without sophisticated computational tools called genome assemblers (short for genome sequence assemblers). Here, we survey the key developments in algorithms for assembling genome sequences since the development of the first DNA sequencing methods more than 35 years ago.
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