Three independent determinants of protein evolutionary rate

TitleThree independent determinants of protein evolutionary rate
Publication TypeJournal Articles
Year of Publication2013
AuthorsChoi S.S, Hannenhalli S
JournalJ Mol EvolJ Mol EvolJ Mol Evol
Date PublishedMar
ISBN Number1432-1432 (Electronic)<br/>0022-2844 (Linking)
Accession Number23400388
Keywords*Evolution, Molecular, *Mutation Rate, Animals, Genes/physiology, Genetic Fitness, HUMANS, Models, Genetic, Protein Biosynthesis/genetics, Protein Folding, Protein Interaction Domains and Motifs/genetics, Proteins/chemistry/*genetics/metabolism

One of the most widely accepted ideas related to the evolutionary rates of proteins is that functionally important residues or regions evolve slower than other regions, a reasonable outcome of which should be a slower evolutionary rate of the proteins with a higher density of functionally important sites. Oddly, the role of functional importance, mainly measured by essentiality, in determining evolutionary rate has been challenged in recent studies. Several variables other than protein essentiality, such as expression level, gene compactness, protein-protein interactions, etc., have been suggested to affect protein evolutionary rate. In the present review, we try to refine the concept of functional importance of a gene, and consider three factors-functional importance, expression level, and gene compactness, as independent determinants of evolutionary rate of a protein, based not only on their known correlation with evolutionary rate but also on a reasonable mechanistic model. We suggest a framework based on these mechanistic models to correctly interpret the correlations between evolutionary rates and the various variables as well as the interrelationships among the variables.

Short TitleJournal of molecular evolutionJournal of molecular evolution
Alternate JournalJournal of molecular evolution