Transcriptional Regulation Via TF-Modifying Enzymes: An Integrative Model-Based Analysis

TitleTranscriptional Regulation Via TF-Modifying Enzymes: An Integrative Model-Based Analysis
Publication TypeJournal Articles
Year of Publication2011
AuthorsEverett LJ, Jensen ST, Hannenhalli S
JournalNucleic Acids ResearchNucl. Acids Res.Nucleic Acids ResearchNucl. Acids Res.
Volume39
Type of Article10.1093/nar/gkr172
ISBN Number0305-1048, 1362-4962
Abstract

Transcription factor activity is largely regulated through post-translational modification. Here, we report the first integrative model of transcription that includes both interactions between transcription factors and promoters, and between transcription factors and modifying enzymes. Simulations indicate that our method is robust against noise. We validated our tool on a well-studied stress response network in yeast and on a STAT1-mediated regulatory network in human B cells. Our work represents a significant step toward a comprehensive model of gene transcription.