Transcriptional Regulation Via TF-Modifying Enzymes: An Integrative Model-Based Analysis
Title | Transcriptional Regulation Via TF-Modifying Enzymes: An Integrative Model-Based Analysis |
Publication Type | Journal Articles |
Year of Publication | 2011 |
Authors | Everett LJ, Jensen ST, Hannenhalli S |
Journal | Nucleic Acids ResearchNucl. Acids Res.Nucleic Acids ResearchNucl. Acids Res. |
Volume | 39 |
Type of Article | 10.1093/nar/gkr172 |
ISBN Number | 0305-1048, 1362-4962 |
Abstract | Transcription factor activity is largely regulated through post-translational modification. Here, we report the first integrative model of transcription that includes both interactions between transcription factors and promoters, and between transcription factors and modifying enzymes. Simulations indicate that our method is robust against noise. We validated our tool on a well-studied stress response network in yeast and on a STAT1-mediated regulatory network in human B cells. Our work represents a significant step toward a comprehensive model of gene transcription. |