CBCB faculty Eytan Ruppin’s group publish a paper in Molecular Systems Biology on computational study of Warburg effect

CBCB faculty Eytan Ruppin's group has published a paper, led by Keren Yizhak, titled “A computational study of the Warburg effect identifies metabolic targets inhibiting cancer migration” on July 30, 2014 in the journal Molecular Systems Biology. This article presents a computational analysis of the Warburg effect, which is a key alteration characterizing the metabolism of many cancers. They show that gene knockouts reverting the Warburg effect can inhibit cancer migration and hence the likelihood of spreading metastasis. Their predictions were further tested and corroborated by their experimental collaborators from Leiden (van de Water) and Cambridge (Frezza).

“A computational study of the Warburg effect identifies metabolic targets inhibiting cancer migration” article: http://onlinelibrary.wiley.com/doi/10.15252/msb.20134993/pdf