Najib El-Sayed

Professor
3246 Iribe Center
(301) 405-2999
Education: 
Ph.D., Yale University
Biography: 

Dr. Najib El-Sayed is an Associate Professor of Cell Biology and Molecular Genetics at the University of Maryland, with a joint appointment in the Center for Bioinformatics and Computational Biology at UMIACS. He received his Ph.D. from Yale University in 1993 in Molecular Parasitology and then trained as a Howard Hughes Medical Institute post-doctoral fellow in the laboratory of John Donelson at the University of Iowa. In 1998, he joined The Institute for Genomic Research (TIGR) in Rockville, Maryland where he led the sequencing, annotation, and comparative and functional genomic analyses of several human pathogens. He has been at the University of Maryland since 2006. He currently directs the Next-Generation Sequencing Core at the University, as well as the Computational Biology, Bioinformatics and Genomics graduate concentration area of studies.

Dr. El-Sayed’s research program is focused on the study of the biology of parasitism and host-pathogen interactions using genomic and bioinformatics approaches with the ultimate goal of better understanding infection and survival mechanisms. These approaches include the development and application of molecular, computational and genomic tools. In the long term, his research will contribute to better diagnosis, prevention and therapeutics of parasite- and bacteria-caused diseases in humans, animals and plants. He has published over 60 research papers and serves on the editorial boards of BMC Genomics and PLoS One. He also serves on NIH’s Genomics, Computational Biology and Technology (GCAT) study section as well as on the Scientific Advisory Board for the National Institute of Allergy and Infectious Diseases’ Genome Sequencing Centers for Infectious Diseases.

Publications

2008


Cerqueira GC, Bartholomeu DC, DaRocha WD, Hou L, Freitas-Silva DM, Machado CRenato, El‐Sayed NM, Teixeira SMR.  2008.  Sequence diversity and evolution of multigene families in Trypanosoma cruzi. Molecular and Biochemical ParasitologyMolecular and Biochemical Parasitology. 157

Bringaud F, Ghedin E, El‐Sayed NM, Papadopoulou B.  2008.  Role of transposable elements in trypanosomatids. Microbes and InfectionMicrobes and Infection. 10

2007


Haas BJ, Berriman M, Hirai H, Cerqueira GG, LoVerde PT, El‐Sayed NM.  2007.  Schistosoma mansoni genome: Closing in on a final gene set. Experimental ParasitologyExperimental Parasitology. 117

Waisberg M, Lobo F, Cerqueira G, Passos L, Carvalho O, Franco G, El‐Sayed NM.  2007.  Microarray analysis of gene expression induced by sexual contact in Schistosoma mansoni. BMC GenomicsBMC Genomics. 8

Souza RT, Santos MRM, Lima FM, El‐Sayed NM, Myler PJ, Ruiz JC, da Silveira JFranco.  2007.  New Trypanosoma cruzi Repeated Element That Shows Site Specificity for Insertion. Eukaryotic CellEukaryotic Cell. 6

Djikeng A., Raverdy S., Foster JS, Bartholomeu D., Zhang Y., El‐Sayed NM, Carlow C..  2007.  Cofactor-independent phosphoglycerate mutase is an essential gene in procyclic form Trypanosoma brucei. Parasitology researchParasitology research. 100

2006


Bringaud F, Ghedin E, Blandin G, Bartholomeu DC, Caler E, Levin MJ, Baltz T, El‐Sayed NM.  2006.  Evolution of non-LTR retrotransposons in the trypanosomatid genomes: Leishmania major has lost the active elements. Molecular and Biochemical ParasitologyMolecular and Biochemical Parasitology. 145

Bringaud F., Bartholomeu D.C, Blandin G., Delcher A., Baltz T., El‐Sayed NM, Ghedin E..  2006.  The Trypanosoma cruzi L1Tc and NARTc non-LTR retrotransposons show relative site specificity for insertion. Molecular biology and evolutionMolecular biology and evolution. 23

2005


MacLeod A., Tweedie A., McLellan S., Taylor S., Hall N., Berriman M., El‐Sayed NM, Hope M., Turner C.MR, Tait A..  2005.  The genetic map and comparative analysis with the physical map of Trypanosoma brucei. Nucleic acids researchNucleic Acids Research. 33

El‐Sayed NM, Myler P.J, Bartholomeu D.C, Nilsson D., Aggarwal G., Tran A.N, Ghedin E., Worthey E.A, Delcher A.L, Blandin G. et al..  2005.  The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease. ScienceScience. 309

Boonyaratanakornkit BB, Simpson AJ, Whitehead TA, Fraser CM, El‐Sayed NM, Clark DS.  2005.  Transcriptional profiling of the hyperthermophilic methanarchaeon Methanococcus jannaschii in response to lethal heat and non‐lethal cold shock. Environmental MicrobiologyEnvironmental Microbiology. 7

Ouhammouch M, Langham GE, Hausner W, Simpson AJ, El‐Sayed NM, E. Geiduschek P.  2005.  Promoter architecture and response to a positive regulator of archaeal transcription. Molecular MicrobiologyMolecular Microbiology. 56

El‐Sayed NM, Myler PJ, Blandin G, Berriman M, Crabtree J, Aggarwal G, Caler E, Renauld H, Worthey EA, Hertz-Fowler C et al..  2005.  Comparative Genomics of Trypanosomatid Parasitic Protozoa. ScienceScience. 309

2004


Bartholomeu D., El‐Sayed NM, Melville S.E.  2004.  Sequencing Strategies for Parasite Genomes. METHODS IN MOLECULAR BIOLOGY-CLIFTON THEN TOTOWA-METHODS IN MOLECULAR BIOLOGY-CLIFTON THEN TOTOWA-. 270

Bringaud F., Biteau N., Zuiderwijk E., Berriman M., El‐Sayed NM, Ghedin E., Melville S.E, Hall N., Baltz T..  2004.  The ingi and RIME non-LTR retrotransposons are not randomly distributed in the genome of Trypanosoma brucei. Molecular biology and evolutionMolecular biology and evolution. 21

El‐Sayed NM, Bartholomeu D, Ivens A, Johnston DA, LoVerde PT.  2004.  Advances in schistosome genomics. Trends in ParasitologyTrends in Parasitology. 20

LoVerde PT, Hirai H, Merrick JM, Lee NH, El‐Sayed NM.  2004.  Schistosoma mansoni genome project: an update. Parasitology InternationalParasitology International. 53

2003


El‐Sayed NM, Ghedin E., Song J., MacLeod A., Bringaud F., Larkin C., Wanless D., Peterson J., Hou L., Taylor S. et al..  2003.  The sequence and analysis of Trypanosoma brucei chromosome II. Nucleic acids researchNucleic Acids Research. 31

2002


Bringaud F, García-Pérez JLuis, Heras SR, Ghedin E, El‐Sayed NM, Andersson B, Baltz T, Lopez MC.  2002.  Identification of non-autonomous non-LTR retrotransposons in the genome of Trypanosoma cruzi. Molecular and Biochemical ParasitologyMolecular and Biochemical Parasitology. 124

Bartholomeu DC, Silva RA, Galvão LMC, El‐Sayed NM, Donelson JE, Teixeira SMR.  2002.  Trypanosoma cruzi: RNA structure and post-transcriptional control of tubulin gene expression. Experimental ParasitologyExperimental Parasitology. 102

Diehl S, Diehl F, El‐Sayed NM, Clayton C, Hoheisel JD.  2002.  Analysis of stage-specific gene expression in the bloodstream and the procyclic form of Trypanosoma brucei using a genomic DNA-microarray. Molecular and Biochemical ParasitologyMolecular and Biochemical Parasitology. 123

Bringaud F., Biteau N., Melville S.E, Hez S., El‐Sayed NM, Leech V., Berriman M., Hall N., Donelson J.E, Baltz T..  2002.  A new, expressed multigene family containing a hot spot for insertion of retroelements is associated with polymorphic subtelomeric regions of Trypanosoma brucei. Eukaryotic cellEukaryotic Cell. 1

2001


LaCount D.J, El‐Sayed NM, Kaul S., Wanless D., Turner C.MR, Donelson J.E.  2001.  Analysis of a donor gene region for a variant surface glycoprotein and its expression site in African trypanosomes. Nucleic acids researchNucleic Acids Research. 29

2000


El‐Sayed NM, Hegde P, Quackenbush J, Melville SE, Donelson JE.  2000.  The African trypanosome genome. International Journal for ParasitologyInternational Journal for Parasitology. 30

1999


Donelson J.E, Gardner M.J, El‐Sayed NM.  1999.  More surprises from Kinetoplastida. Proceedings of the National Academy of Sciences of the United States of AmericaProceedings of the National Academy of Sciences of the United States of America. 96

1998


Donelson JE, Hill KL, El‐Sayed NM.  1998.  Multiple mechanisms of immune evasion by African trypanosomes. Molecular and Biochemical ParasitologyMolecular and Biochemical Parasitology. 91

1997


El‐Sayed NM, Donelson JE.  1997.  A survey of the Trypanosoma brucei rhodesiense genome using shotgun sequencing. Molecular and Biochemical ParasitologyMolecular and Biochemical Parasitology. 84

1996


Morgan R.W, El‐Sayed NM, Kepa J.K, Pedram M., Donelson J.E.  1996.  Differential expression of the expression site-associated gene I family in African trypanosomes. Journal of Biological ChemistryJournal of Biological Chemistry. 271

1995


El‐Sayed NM, Alarcon CM, Beck JC, Sheffield VC, Donelson JE.  1995.  cDNA expressed sequence tags of Trypanosoma brucei rhodesiense provide new insights into the biology of the parasite. Molecular and Biochemical ParasitologyMolecular and Biochemical Parasitology. 73

El‐Sayed NM, Patton C.L, Harkins P.C, Fox R.O, Anderson K..  1995.  Crystallization and preliminary X-ray investigation of the recombinant Trypanosoma brucei rhodesiense calmodulin. Proteins: Structure, Function, and BioinformaticsProteins: Structure, Function, and Bioinformatics. 21