CTCF binding site classes exhibit distinct evolutionary, genomic, epigenomic and transcriptomic features

TitleCTCF binding site classes exhibit distinct evolutionary, genomic, epigenomic and transcriptomic features
Publication TypeJournal Articles
Year of Publication2009
AuthorsEssien K, Vigneau S, Apreleva S, Singh LN, Bartolomei MS, Hannenhalli S
JournalGenome BiologyGenome Biology
Volume10
Type of Article10.1186/gb-2009-10-11-r131
ISBN Number1465-6906
Abstract

CTCF (CCCTC-binding factor) is an evolutionarily conserved zinc finger protein involved in diverse functions ranging from negative regulation of MYC, to chromatin insulation of the beta-globin gene cluster, to imprinting of the Igf2 locus. The 11 zinc fingers of CTCF are known to differentially contribute to the CTCF-DNA interaction at different binding sites. It is possible that the differences in CTCF-DNA conformation at different binding sites underlie CTCF's functional diversity. If so, the CTCF binding sites may belong to distinct classes, each compatible with a specific functional role.