Publications

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2014
Jerby-Arnon L, Pfetzer N, Waldman YY, McGarry L, James D, Shanks E, Seashore-Ludlow B, Weinstock A, Geiger T, Clemons PA et al..  2014.  Predicting cancer-specific vulnerability via data-driven detection of synthetic lethality.. Cell. 158(5):1199-209.
2015
Rabinovich S, Adler L, Yizhak K, Sarver A, Silberman A, Agron S, Stettner N, Sun Q, Brandis A, Helbling D et al..  2015.  Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis. Nature. 527(7578):379-383.
Rabinovich S, Adler L, Yizhak K, Sarver A, Silberman A, Agron S, Stettner N, Sun Q, Brandis A, Helbling D et al..  2015.  Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis. Nature. 527(7578):379-383.
Wagner A, Cohen N, Kelder T, Amit U, Liebman E, Steinberg DM, Radonjic M, Ruppin E.  2015.  Drugs that reverse disease transcriptomic signatures are more effective in a mouse model of dyslipidemia.. Mol Syst Biol. 11(3):791.
Wagner A, Cohen N, Kelder T, Amit U, Liebman E, Steinberg DM, Radonjic M, Ruppin E.  2015.  Drugs that reverse disease transcriptomic signatures are more effective in a mouse model of dyslipidemia.. Mol Syst Biol. 11(3):791.
Uziel O, Yosef N, Sharan R, Ruppin E, Kupiec M, Kushnir M, Beery E, Cohen-Diker T, Nordenberg J, Lahav M.  2015.  The effects of telomere shortening on cancer cells: a network model of proteomic and microRNA analysis.. Genomics. 105(1):5-16.
Pop M.  2015.  Encyclopedia of MetagenomicsHuman Microbiome, Assembly and Analysis Software, Project. :243-246.
Rangarajan N, Kulkarni P, Hannenhalli S.  2015.  Evolutionarily conserved network properties of intrinsically disordered proteins.. PLoS One. 10(5):e0126729.
Ish-Am O, Kristensen DM, Ruppin E.  2015.  Evolutionary Conservation of Bacterial Essential Metabolic Genes across All Bacterial Culture Media. PLOS ONE. 10(4):e0123785.
Zheng L, Cardaci S, Jerby L, MacKenzie ED, Sciacovelli M, T Johnson I, Gaude E, King A, Leach JDG, Edrada-Ebel RA et al..  2015.  Fumarate induces redox-dependent senescence by modifying glutathione metabolism.. Nat Commun. 6:6001.
Tardito S, Oudin ïs, Ahmed SU, Fack F, Keunen O, Zheng L, Miletic H, Sakariassen Ø, Weinstock A, Wagner A et al..  2015.  Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma. Nature Cell Biology. 17(12):1556-1568.
Tardito S, Oudin ïs, Ahmed SU, Fack F, Keunen O, Zheng L, Miletic H, Sakariassen Ø, Weinstock A, Wagner A et al..  2015.  Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma. Nature Cell Biology. 17(12):1556-1568.
Oberhardt MA, Zarecki R, Gronow S, Lang E, Klenk H-P, Gophna U, Ruppin E.  2015.  Harnessing the landscape of microbial culture media to predict new organism-media pairings.. Nat Commun. 6:8493.
Seaver SMD, Bradbury LMT, Frelin O, Zarecki R, Ruppin E, Hanson AD, Henry CS.  2015.  Improved evidence-based genome-scale metabolic models for maize leaf, embryo, and endosperm.. Front Plant Sci. 6:142.
Takala-Harrison S., Jacob C.G, Arze C., Cummings MP, Silva J.C, Dondorp A.M, Fukuda M.M, Hien T.T, Mayxay M., Noedl H. et al..  2015.  Independent Emergence of Artemisinin Resistance Mutations Among Plasmodium falciparum in Southeast Asia. Journal of Infectious Diseases. 211:670-679.
Yizhak K., Chaneton B., Gottlieb E., Ruppin E..  2015.  Modeling cancer metabolism on a genome scale. Molecular Systems Biology. 11(6):817-817.
Regier JC, Mitter C, KRISTENSEN NIELSP, Davis DR, VAN NIEUKERKEN ERIKJ, ROTA JADRANKA, Simonsen TJ, Mitter KT, Kawahara AY, Yen S-H et al..  2015.  A molecular phylogeny for the oldest (nonditrysian) lineages of extant Lepidoptera, with implications for classification, comparative morphology and life-history evolution. Systematic Entomology. :n/a-n/a.
Regier JC, Mitter C, KRISTENSEN NIELSP, Davis DR, VAN NIEUKERKEN ERIKJ, ROTA JADRANKA, Simonsen TJ, Mitter KT, Kawahara AY, Yen S-H et al..  2015.  A molecular phylogeny for the oldest (nonditrysian) lineages of extant Lepidoptera, with implications for classification, comparative morphology and life-history evolution. Systematic Entomology. :n/a-n/a.
Jerby-Arnon L, Ruppin E.  2015.  Moving ahead on harnessing synthetic lethality to fight cancer. Molecular & Cellular Oncology. 2(2):e977150.
Huber W, Carey VJ, Gentleman R, Anders S, Carlson M, Carvalho BS, Bravo HCorrada, Davis S, Gatto L, Girke T et al..  2015.  Orchestrating high-throughput genomic analysis with Bioconductor.. Nat Methods. 12(2):115-21.
Patella F, Schug ZT, Persi E, Neilson LJ, Erami Z, Avanzato D, Maione F, Hernandez-Fernaud JR, Mackay G, Zheng L et al..  2015.  Proteomics-based metabolic modeling reveals that fatty acid oxidation (FAO) controls endothelial cell (EC) permeability.. Mol Cell Proteomics. 14(3):621-34.
Patella F, Schug ZT, Persi E, Neilson LJ, Erami Z, Avanzato D, Maione F, Hernandez-Fernaud JR, Mackay G, Zheng L et al..  2015.  Proteomics-based metabolic modeling reveals that fatty acid oxidation (FAO) controls endothelial cell (EC) permeability.. Mol Cell Proteomics. 14(3):621-34.
Megchelenbrink W, Katzir R, Lu X, Ruppin E, Notebaart RA.  2015.  Synthetic dosage lethality in the human metabolic network is highly predictive of tumor growth and cancer patient survival.. Proc Natl Acad Sci U S A.
2016
Auslander N, Wagner A, Oberhardt M, Ruppin E.  2016.  Data-Driven Metabolic Pathway Compositions Enhance Cancer Survival Prediction. PLOS Computational Biology. 12(9):e1005125.
Mazza A, Wagner A, Ruppin E, Sharan R.  2016.  Functional Alignment of Metabolic Networks.. J Comput Biol.

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